“ CDNF is now one of a few clinical stage assets in development with the potential for disease modification of Parkinson’s Disease. The intranasal administration route of CDNF is an important program for Herantis to maximize the chances of success for CDNF in brain disorders.

10.45 Herantis Pharma – CEO Pekka Simula assets based on globally leading science in their fields: CDNF for neurodegenerative diseases,

29.3.2021 Digitalous · Legendaarisesta scifi-tähdestä tehtiin (CDNF) infusion till patienter med PS av måttlig svårighetsgrad. Studien har fått EU stöd och sponsorn är Herantis Pharma (https://treater.eu; ClinicalTrials. gov Herantis Pharma är ett finländskt läkemedelsutvecklingsbolag som i kliniska studier – CDNF mot Parkinsons och Lymfactin mot lymfödem. Herantis Pharma meddelar att toplinedata från bolagets fas I-II-studie med kandidaten CDNF för behandling av patienter med Parkinsons 2020-08-27 08:00:00 Herantis Pharma Herantis Pharma Oyj: Herantiksen CDNF on turvallinen ja hyvin siedetty Vaiheen 1-2 tutkimuksessa 12 6 April, 17:00. DI - 2020-12-17 18:15:14. Nanoform and Herantis partner to look for opportunities to enhance BBB penetration of CDNF and xCDNF molecules of Herantis' CDNF therapies for Parkinson's disease using Nanoform's proprietary biological nanoparticle technology. As a result, Nanoform Herantis Pharma meddelade att en behandling som kallas cerebral dopamin neurotrofisk faktor (CDNF) har beviljats särläkemedelsstatus av Teknisk analys Herantis Pharma (HRNTS).

Herantis cdnf

2019-08-28 Herantis also announced today the next step for the CDNF program with the planning of a Phase 2 study with a longer treatment period that will assess the efficacy of CDNF in earlier-stage, well-characterized Parkinson’s patients. 2020-03-05 Supported by a strong preclinical proof-of-concept Herantis launched a first-in-human, randomized Phase 1-2 clinical study with CDNF in the treatment of Parkinson's disease (PD). The clinical study has received funding from the European Union's research and innovation program Horizon 2020 under the grant agreement number 732386. Subject to finalizing definitive agreements, Nanoform will in this partnership carry out, for compensation on standard commercial terms, two Proof of Concept studies on Herantis' CDNF and xCDNF Nanoform is committed to supporting Herantis in the development of these programs and has undertaken to invest, subject to certain customary conditions, 1,600,000 euros in a planned immediate directed share issue by Herantis. “We are delighted to support Herantis Pharma in their development programs in CDNF and latest generation xCDNF molecules. Nanoform Finland and Herantis Pharma have announced that they have signed a Biologics Proof of Concept Agreement for formulation Proof of Concept projects (PoCs) aiming to enhance nasal drug delivery to the brain of Herantis’ CDNF therapies for Parkinson’s disease using Nanoform’s biological nanoparticle technology.

Nanoform and Herantis partner to look for opportunities to enhance BBB penetration of CDNF and xCDNF molecules

With the main study of the Phase I/II cerebral dopamine neurotrophic factor (CDNF) study now complete in Parkinson’s disease (PD) (top-line safety and efficacy data are expected in Q120), positive trial data could validate the research efforts and enable future partnering opportunities. Herantis Pharma Oyj ("Herantis" tai "Yhtiö") tiedotti tänään alustavia tuloksia CDNF-lääkeaihion Vaiheen 1-2 kliinisestä tutkimuksesta Parkinsonin tautia sairastavissa potilaissa. CDNF on Herantiksen yksinoikeudella kehittämä, hermosoluja suojaava lääkeaihio, jonka tavoitteena on muuttaa Parkinsonin taudinkulkua, mikä olisi merkittävä läpimurto verrattuna tunnettuihin In order to do this, Herantis has developed xCDNF, a patented, chemically synthesised form of CDNF that uses small but potent biologically active fragments of the parent CDNF molecule, which it says can reach the key areas of the brain in therapeutic concentrations using a simple dosing method such as subcutaneous injection.

Supported by a strong preclinical proof-of-concept Herantis launched a first-in-human, randomized Phase 1-2 clinical study with CDNF in the treatment of Parkinson's disease (PD). The clinical study has received funding from the European Union's research and innovation program Horizon 2020 under the grant agreement number 732386.

Key assets include CDNF for Parkinson’s disease and Lymfactin for breast cancer associated lymphedema. 2021-03-11 Herantis Pharma Plc Company release, insider information 25 February 2020 at 9:00 AM Eastern European Time. Herantis Pharma Plc ("Herantis" or "Company") announced today the topline results from the ongoing Phase 1-2 clinical trial examining Herantis' proprietary neuroprotective factor and novel drug candidate, CDNF, in patients with Parkinson Herantis is currently exploring other less invasive, more patient-friendly ways to deliver CDNF to patients. This includes certain parenteral routes and intranasal administration. In addition to Parkinson’s disease, CDNF has shown potent neuroprotective and neurorestorative effects in preclinical models of several other neurodegenerative conditions.

Based on this discovery, Herantis has secured worldwide patents for CDNF and launched a drug development program.
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En känd utmaning i läkemedelsvärlden vid behandling av hjärnan är att ta sig förbi blod-hjärnbarriären. Herantis Pharma är noterat på Nasdaq First North i både Stockholm och Helsingfors.

The products of the group are CDNF for Parkinson's disease, Lymfactin for secondary Herantis Pharma är ett finskt forskningsbolag noterat i Helsingfors, med två mot Parkinsons sjukdom är ett naturligt protein som heter CDNF. 10.45 Herantis Pharma – CEO Pekka Simula assets based on globally leading science in their fields: CDNF for neurodegenerative diseases, Herantis ~ Nanoform har tecknat en avsiktsförklaring med läkemedelsbolaget Herantis kring att utforska så kallad BBBpenetration av CDNF Herantis Pharma sai harvinaislääkestatuksen CDNF-lääkeaihiolle · Henri Huttunen. 29/03/2016. 1 objekt av Mediabevakning.
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2021-03-10

We aim to develop our products through clinical proof-of-concept and, where considered appropriate, to partner with large pharmaceutical or biotech companies for late-stage development and commercialization. 2021-03-10 Herantis Pharma Oyj: Herantis Pharma to focus on CDNF and xCDNF programs 2021-03-25 07:00 · Cision Herantis Pharma Oyj: Herantis Pharma Published the Annual Report for the Financial Year 2020 Herantis Pharma Plc (“Herantis” or “Company”) announced today an update on the development of its non-invasive next generation CDNF, or xCDNF. The xCDNF development program was initiated in July 2018 to develop cell-protecting molecules that penetrate the blood-brain barrier, building on the Company’s cumulated expertise on CDNF, Herantis’ lead compound in Parkinson disease. 2019-09-26 Herantis Pharma Plc. Company release, Inside Information 29 March 2021 at 9:00 PM EET. Herantis Pharma Plc ("Herantis or the Company"), an innovative clinical stage biotech company pioneering new disease modifying and regenerative therapies, today announced that the Board of Directors has decided to focus all company resources on Herantis' CDNF and xCDNF assets and to commence seeking out 2017-10-02 Thus, Herantis has decided to evaluate the best path forward with its clinical stage asset CDNF, using alternative administration methods. Instead of committing significant resources towards a Phase II study involving an implanted surgical device the company has, at this stage, resolved to pursue more patient-friendly modes of delivery that do not require the need for a surgical device. Herantis Pharma keskittyy CDNF- ja xCDNF-ohjelmiin Herantis Pharma Oyj (“Herantis” tai “Yhtiö”),. Kuten aikaisemmassa Yhtiön tiedotteessa 2.3.2021 kerrottiin, Lymfactinin Webinaariin voi rekisteröityä alle olevasta linkistä..

CDNF för användande vid intranasal behandling av sjukdomar i centrala nervsystemet. A61K38/18; A61P25/00; A61P25/16; A61P25/28. Herantis Pharma Plc.

Herantis Pharma is focused on the development of innovative regenerative medicines targeting unmet needs. The recent virtual capital markets day highlighted the progress of its two innovative assets: cerebral dopamine neurotrophic factor (CDNF), a potential disease-modifying treatment for Parkinsonâ s disease (PD); and Lymfactin, the only gene therapy in development for breast cancer Herantis Pharma is a Finnish innovative biopharmaceutical company focusing on regenerative medicines for unmet needs.

The study will also involve Herantis has announced top-line data from the first part of the Phase I/II clinical trial on novel asset CDNF in Parkinson’s disease (PD).